Monday morning, Sen. Barbara Mikulski surprised the political world by announcing that she would not seek reelection in 2016, immediately setting off a day of wild speculation about potential contenders to fill her shoes.

Then, this morning, the presumed Democratic frontrunner for her seat, former Maryland Gov. Martin O’Malley, issued a statement praising Mikulski’s record, but declaring that he would not be a candidate for her office. He has been, after all, making the rounds in Iowa, New Hampshire, and South Carolina—early presidential primary states—where, it is presumed, he will eventually throw his hat in the ring.

Which brings us to renowned former Johns Hopkins’ neurosurgeon Dr. Ben Carson. The 63-year-old conservative Republican launched a formal presidential exploratory committee Tuesday—a key move that allows him to start raising money now for a campaign should he decide to enter the race. He made the announcement via video on his new website, which highlights his compelling personal story, groundbreaking career in pediatric neurosurgery, and philanthropy.

In his nearly 4-minute video announcement, Carson, who has never held elected office, says, “All of us are frustrated with the way Washington has let us down. Career politicians simply don’t understand the disappointment, anger, and pain in real America.”

He says that if he receives enough encouragement and support over the next few months, he’ll make for a run for president.

Although Carson has at times created controversy with his public remarks, such as expressing his opposition to same-sex marriage and Obamacare, as well as his creationist views, he remains popular among conservatives. At the recent, annual Conservative Political Action Conference in National Harbor, MD, Carson finished fourth in the straw poll with 11.4 percent of the vote, after Kentucky Sen. Rand Paul with 25.7 percent, Wisconsin Gov. Scott Walker with 21.4 percent, and Texas Sen. Ted Cruz with 11.5 percent.

It’s worth noting that Carson outpolled former Florida Gov. Jeb Bush, who finished with 8.3 percent of the tally, as well as Florida Sen. Marco Rubio, New Jersey Gov. Chris Christie, and Texas Gov. Rick Perry—all of whom received less than 4 percent of the vote. Carson, who has often appeared on Fox News as a political commentator, discussed his potential bid on Meet the Press this past weekend. At this point, there seems little to indicate why he wouldn’t run.

In fact, Carson, who talks often about his religious faith, may play particularly well in the Iowa Republican caucus and South Carolina primary if former Gov. Mike Huckabee does not enter the race.

O’Malley, on the other hand, has struggled to make much of dent in national Democratic presidential polls, and recently tried to distance himself from Hillary Clinton.

Time will tell if Carson or O’Malley will be able to gain traction in their potential primary campaign efforts, but what does seem clear is that neither man lacks ambition for the job.

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Elected to the House of Representatives in 1976, the Highlandtown-native and Democrat won Maryland’s 1986 Senate race, and is the longest-serving woman in Congressional history.

The 78-year-old former social worker turned activist turned politician has been a vocal advocate for Maryland and liberal causes in the Senate from the start. She also became the
first woman to chair the powerful Appropriations Committee, a committee where she’s served since entering the Senate.

At her press conference, Mikulski highlighted the symbolism of making her announcement in Fells Point in Southeast Baltimore, where she became politically engaged in the ultimately successful 1970s fight to prevent a six-lane elevated highway through the historic port neighborhood. “It’s where I learned that we are all in this together . . . And it’s where I learned about service from my mother and father who said, ‘Good morning, can I help you?’ every morning when they opened the small neighborhood grocery they owned and ran.”

In making her decision, Mikulski, who got emotional briefly in talking about her staff and close working relationship with Maryland Sen. Ben Cardin, said she had thought “long and hard” about how best to spend the next two years. “I had to decide whether to spend my time fighting to keep my job or fighting for your job,” said Mikulski, who appears, despite the passing years, as energetic and spirited as ever. “Do I spend my time raising money or raising hell to meet your day-to-day needs?”

Over the next two years in the Senate, Mikulski said, she’d “be fighting to give families a raise by finishing what we started with the Lily Ledbetter Fair Pay Act and passing the Paycheck Fairness Act, once and for all guaranteeing equal pay for equal work. I’ll be fighting for a family-friendly tax code with targeted tax breaks, doubling the child care tax credit to make child care affordable.” Mikulski added that she has not yet given serious consideration to what she might do after leaving the Senate—other than perhaps spending more time lingering over morning coffee at the Daily Grind in Fells Point.

Cardin, who was on hand for the announcement, called Mikulski’s decision a “bittersweet” moment.

“Her record is incredible and we celebrate that today,” said Cardin, who has known Mikulski since the early 1970s when she served on the Baltimore City Council and he was a member Maryland House of Delegates. “She’s a fighter who broke many glass ceilings.”

Cardin said, like many, he was surprised by Mikulski’s decision, which she told him about yesterday. He added that Mikulski certainly would’ve been favored to win reelection if she’d chosen to run again.

Immediately following the announcement of the
Mikulski press conference this morning, speculation began about who would run to take her place in 2016.

The name mentioned most often is former Gov. Martin O’Malley, who has been seriously considering a
presidential bid for sometime. O’Malley, whose mother has long worked in Mikulski’s D.C. office, is considered a long shot for the Democratic nomination with Hillary Clinton’s projected campaign.

After her opening statement, Mikulski addressed a question about the potential 2016 field for the state’s open seat, noting with a smile that, “Maryland has a lot of talent and they’ll be telling you about it in the next 10 minutes.”

Other members of the Maryland congressional delegation, including
Rep. Elijah Cummings and Rep. Chris Van Hollen, are being discussed as potential candidates to fill Mikulski’s shoes. According to The Washington Post, Rep. Dutch Ruppersberger’s staff has said “it’s safe to say” that he’ll consider running for Mikulski’s seat.

On the Republican side, renowned former Johns Hopkins’ neurosurgeon Ben Carson has been floating a potential presidential bid and could consider
setting his sights on the Senate. Former Gov. Robert Ehrlich, who previously served in the U.S. House of Representatives, may also consider a bid for Mikulski’s seat.

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